To setup notepad++ to execute sql scripts that you are writing do the following:

1.  Be sure that you have the nppexec plugin installed.

2. Hit F6 to open the nppexec execute window.

3.  In the Commands window type the following command…

SQLCMD.EXE -E -S.\SqlExpress -i “$(FULL_CURRENT_PATH)” -deScore

4.  Click Save and give the nppexec script a name.  Make a mental note of the scripts name.

5.  Click on Settings/Shortcut Mapper and choose the Plugin commands tab.

6.  Scroll through the list and find your new script (given in step 4).

7.  Double click the script and assign a keystroke to the script.  (I use ctrl-alt-F5)

Test it out.

Enjoy.